Data from: Unlocking the therapeutic potential of T-DXd (Enhertu): Insights into mechanisms of action in HER2-low cancers and immunomodulatory effects

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  • These data are produced by LC/MS/MS analysis of plasma and tumor samples collected in mouse tumor treatment studies, utilizing T-Dxd (Enhertu) is a novel antibody-drug-conjugate (ADC) targeting HER2. After development of fit-for-purpose assays on Shimadzu 20A series/Applied Biosystems-SCIEX LC/MS/MS, study samples were assayed against calibration standard samples and peak area integration and quantification was performed by Analyst 1.6.2.

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11 files (2.48 MB)
Data Citation
  • Fan, P. & Spasojevic, I. (2024). Data from: Unlocking the therapeutic potential of T-DXd (Enhertu): Insights into mechanisms of action in HER2-low cancers and immunomodulatory effects. Duke Research Data Repository. https://doi.org/10.7924/r4862qh18
DOI
  • 10.7924/r4862qh18
Publication Date
ARK
  • ark:/87924/r4862qh18
Collection Dates
  • 2023-12-07/ 2024-05-22
Type
Related Materials
  • Dumontet, C., Reichert, J. M., Senter, P. D., Lambert, J. M., & Beck, A. (2023). Antibody-drug conjugates come of age in oncology. Nature Reviews. Drug Discovery, 22(8), 641-661.  https://doi.org/10.1038/s41573-023-00709-2
  • Tsao, L., Crosby, E. J., Trotter, T. N., Agarwal, P., Hwang, B., Acharya, C., Shuptrine, C. W., Wang, T., Wei, J., Yang, X., Lei, G., Liu, C., Rabiola, C. A., Chodosh, L. A., Muller, W. J., Lyerly, H. K., & Hartman, Z. C. (2019). CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. JCI Insight, 4(24) https://doi.org/10.1172/jci.insight.131882
  • Bournazos, S., Gupta, A., & Ravetch, J. V. (2020). The role of IgG fc receptors in antibody-dependent enhancement. Nature Reviews. Immunology, 20(10), 633-643.  https://doi.org/10.1038/s41577-020-00410-0
  • Tsao, L., Force, J., & Hartman, Z. C. (2021). Mechanisms of therapeutic antitumor monoclonal antibodies. Cancer Research (Chicago, Ill.), 81(18), 4641-4651.  https://doi.org/10.1158/0008-5472.can-21-1109
Funding Agency
  • National Institutes of Health
  • National Cancer Institute
Grant Number
  • P30CA014236
Title
  • Data from: Unlocking the therapeutic potential of T-DXd (Enhertu): Insights into mechanisms of action in HER2-low cancers and immunomodulatory effects
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