- Chlamydiae are obligate intracellular bacterial pathogens that may cause genital pathology via induction of destructive host immune responses. Human-adapted Chlamydia trachomatis causes inflammatory disease in human hosts but is easily cleared in mice, and mouse-adapted Chlamydia muridarum establishes a productive and pathogenic infection in murine hosts. While numerous anti-chlamydial host resistance factors have been discovered in mice and humans alike, little is known about host factors promoting host fitness independent of host resistance. Here, we show that interferon-inducible immunity-related GTPase M (Irgm) proteins function as such host factors ameliorating infection-associated sequalae in the murine female genital tract, thus characterizing Irgm proteins as mediators of disease tolerance. ... [Read More]
- Total Size
- 9 files (109 KB)
- Data Citation
- Dockterman, J., Reitano, J. R., Everitt, J. I., Wallace, G. D., Hendrix, M., Taylor, G. A., & Coers, J. (2024). Data from: Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection. Duke Research Data Repository. https://doi.org/10.7924/r4r214s79
- Creator
- DOI
- 10.7924/r4r214s79
- Subject
- Publication Date
- May 28, 2024
- ARK
- ark:/87924/r4r214s79
- Publisher
- Type
- Related Materials
- Funding Agency
- National Institute of Allergy and Infectious Disease
- Grant Number
- AI103197
- Title
- Data from: Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection
- Repository
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