Data from: Gene delivery from granular scaffolds for tunable biologics manufacturing

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  • The following dataset corresponds to all raw data and figures for the manuscript: E. Kurt, G. Devlin, A. Asokan, T. Segura, Gene Delivery From Granular Scaffolds for Tunable Biologics Manufacturing. Small 2024, 20, 2309911. https://doi.org/10.1002/smll.202309911

    Our understanding of the molecular basis for disease has generated a myriad of therapeutic biologics, including therapeutic proteins, antibodies, and viruses. However, the promise that biologics can resolve currently incurable diseases hinges in their manufacturability. These therapeutics require that their genetic material be introduced to mammalian cells such that the cell machinery can manufacture the biological components. These are then purified, validated, and packaged. Most manufacturing uses batch processes that collect the biologic a few days following genetic modification, due to toxicity or difficulty in separating product from cells in a continuous operation, limiting the amount of biologic that can be produced and resulting in yearlong backlogs. Here, a scaffold-based approach for continuous biologic manufacturing is presented, with sustained production of active antibodies and viruses for 30 days. The use of a scaffold-based biologic production enabled perfusion-based bioreactors to be used, which can be incorporated into a fully continuous process.
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13 files (350 MB)
Data Citation
  • Kurt, E., Devlin, G., Asokan, A., & Segura, T. (2024). Data from: Gene delivery from granular scaffolds for tunable biologics manufacturing. Duke Research Data Repository. https://doi.org/10.7924/r4280h775
DOI
  • 10.7924/r4280h775
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ARK
  • ark:/87924/r4280h775
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Funding Agency
  • National Institutes of Health
  • National Institute of General Medical Sciences
Grant Number
  • T32GM008555
  • R01NS094599
Title
  • Data from: Gene delivery from granular scaffolds for tunable biologics manufacturing
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