Few of the many chemicals that regulatory agencies are charged with assessing for risk have been carefully tested for developmental neurotoxicity (DNT). To speed up testi[...]

The gut microbiome can influence host health by facilitating digestion immune function and xenobiotic metabolism. Microbial metabolites can influence mitochondrial funct[...]

Background: Diets high in saturated fat and sugar termed 'western diets' have been associated with several negative health outcomes including increased risk for neurodege[...]

Inhibitors of electron transport chain Complex I (CI) have long been associated with and are now used to model Parkinson's disease (PD), but CI inhibition results in mult[...]

Mitochondrial bioenergetic processes are fundamental to development stress responses and health. Caenorhabditis elegans is widely used to study developmental biology mito[...]

Parental exposure to toxicants can affect progeny health including when those exposures occur prior to conception. However most published preconception studies have invol[...]

Human exposure to polycyclic aromatic hydrocarbons (PAH) is a significant public health problem that will worsen with a warming climate and increased large-scale wildfire[...]

Typical environmental exposures to the toxic class of chemicals known as polycyclic aromatic hydrocarbons (PAHs) involve complex mixtures; however, relatively few mechani[...]

Environmental factors including chemical exposures are important contributors to Parkinson's disease (PD). Nearly all well-validated chemicals involved in PD affect mitoc[...]

The abstract follows; full data details are in the readme file.

Background: Sex differences in mitochondrial function have been reported in multiple tissue and [...]