Data and code from: MAP Crosslinker Chirality Regulates Macrophage Polarization via MD-2 Binding and Enables Tunable Immunomodulation Through Novel Peptide Design

This dataset contains the raw and processed data supporting the manuscript "MAP Crosslinker Chirality Regulates Macrophage Polarization via MD-2 Binding and TLR4 Signaling". Data include flow cytometry measurements of macrophage phenotypes, cytokine quantification assays, surface plasmon resonance (SPR) binding experiments, molecular docking analyses, and in vivo wound healing outcomes. The study investigates how peptide crosslinker chirality within microporous annealed particle (MAP) scaffolds influences macrophage activation and tissue repair through interactions with the immune receptor MD-2 and associated TLR4 signaling pathways. Data are organized by figure and include source data used to generate all plots presented in the manuscript. Statistical analyses were performed using GraphPad Prism (version 11), and flow cytometry analyses were performed using FlowJo and FlowSOM as described in the associated manuscript.