This study assessed firefighter’s ambient (non-dietary) exposure to PFASs using silicone wristbands. Twenty-three firefighters from North Carolina wore a new wristband during a 9-day work period and repeated the process for approximately 4 months. While wearing the wristbands, each firefighter reported on fire calls using an App installed on their phones. Wristbands, and blood plasma samples collected at study completion, were analyzed for PFASs. Wristband samples were analyzed for both volatile and non-volatile PFAS using GC- and LC-mass spectrometry approaches. Plasma was analyzed for non-volatile PFAS using LC-MS/MS.