- Nicotine is an addictive substance that poses significant health and societal challenges. Despite the known links between the medial habenula (MHb) and nicotine avoidance, the ionic mechanisms underlying MHb neuronal responses to nicotine remain unclear. Here we report that MHb neurons employ a long-lasting refractory period (LLRP) as an unconventional inhibitory mechanism to curb hyperexcitability. This process is initiated by nicotine-induced calcium influx through nicotinic acetylcholine receptors (nAChRs), which activates a calcium-activated chloride conductance (CaCC). Due to high intracellular chloride levels in MHb neurons, chloride efflux through CaCC, coupled with high-threshold voltage-gated calcium channels (VGCCs), sustains MHb depolarization near the chloride equilibrium potential of -30 mV, ... [Read More]
- Total Size
- 6 files (2.86 MB)
- Data Citation
- Yang, H., Dong, P., Kawai, T., & Yin, H. H. (2024). Data from: Calcium-activated ion channels drive atypical inhibition in medial habenula neurons. Duke Research Data Repository. https://doi.org/10.7924/r4w95d459
- DOI
- 10.7924/r4w95d459
- Publication Date
- October 9, 2024
- ARK
- ark:/87924/r4w95d459
- Affiliation
- Publisher
- Type
- Contact
- Yang, Huanghe, huanghe.yang@duke.edu
- Title
- Data from: Calcium-activated ion channels drive atypical inhibition in medial habenula neurons
- Repository
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
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README.pdf | 2024-10-09 | Download | |
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01_Summarized_data_saline.xlsx | 2024-10-09 | Download | |
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MHb_Nicotine.m | 2024-10-09 | Download | |
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02_Summarized_data_0.1 low nicotine.xlsx | 2024-10-09 | Download | |
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03_Summarized_data_0.5 nicotine.xlsx | 2024-10-09 | Download | |
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MHb_single_unit_firing_plot.m | 2024-10-09 | Download |
README or associated documentation cannot be displayed. Please reference the file list.