• *Data embargoed until publication of related article, or up to no more than 1 year from data upload.*
  
  Electrical stimulation of the enteric nervous system (ENS) is an attractive approach to modify gastrointestinal transit. Colonic motor complexes (CMCs) occur with a periodic rhythm, but the ability to elicit a premature CMC depends, at least in part, upon the intrinsic refractory properties of the ENS, which are presently unknown. The objectives of this study were to record myoelectric complexes (MCs, the electrical correlates of CMCs) in the smooth muscle and (i) determine the refractory periods of MCs, (ii) inform and evaluate closed-loop stimulation to repetitively evoke MCs, and (iii) identify stimulation methods to suppress MC propagation. We dissected the colon from male and female C57BL/6 mice, preserving the integrity of intrinsic circuitry while removing the extrinsic nerves, and measured properties of spontaneous and evoked MCs in vitro. Hexamethonium abolished spontaneous and evoked MCs, confirming the necessary involvement of the ENS for electrically-evoked MCs. Electrical stimulation reduced the mean interval between evoked and spontaneous CMCs (24.6 ± 3.5 vs 70.6 ± 15.7 s, p = 0.0002, n = 7). The absolute refractory period was 4.3 s (95% CI = 2.8 - 5.7 s, R2 = 0.7315, n = 8). Electrical stimulation lead to arrest of fluid distention-evoked propagating MC, and following cessation of stimulation propagation resumed at an increased velocity (n = 9). The timing parameters of electrical stimulation increased the rate of evoked MCs, including the duration of entrained MCs, and provide insights into timing considerations for designing neuromodulation strategies to treat colonic dysmotility. ... [Read More]

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Data Citation

• Barth, B., Grill, W., Spencer, N., & Travis, L. (2020). Data from: The control of colonic motility using electrical stimulation to modulate enteric neural circuitry. Duke Research Data Repository. https://doi.org/10.7924/r4bk1dq8n

Creator

• Grill, Warren
• Travis, Lee
• Spencer, Nick
• Barth, Bradley

DOI

• 10.7924/r4bk1dq8n

Subject

• Closed-loop controller
• Enteric nervous system
• Neuromodulation
• Colonic motor complex
• Neurogastroenterology

Publication Date

• October 6, 2020

ARK

• ark:/87924/r4bk1dq8n

Affiliation

• Biomedical Engineering
• Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Centre for Neuroscience, Flinders University, Bedford Park, South Australia, 5042, Australia

Publisher

• Duke Research Data Repository

Type

• Dataset

Format

• TXT
• CSV

Contact

• Bradley Barth; bradley.barth@duke.edu, ORCID 0000-0002-4344-7182

Rights

• Creative Commons BY Attribution 4.0 International

Title

• Data from: The control of colonic motility using electrical stimulation to modulate enteric neural circuitry

Rights

• https://creativecommons.org/licenses/by/4.0/

Repository

• Duke Research Data Repository

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