Data from: Self-assembling allergen vaccine platform raises therapeutic allergen-specific IgG responses without induction of systemic allergic responses

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  • Allergen immunotherapies are often successful at desensitizing allergic patients but can require life-long dosing and suffer from frequent adverse events including instances of systemic anaphylaxis, leading to poor patient compliance and high cost. Allergen vaccines, in turn, can generate more durable immunological allergen desensitization with far fewer doses. However, like immunotherapies, allergen vaccines are often highly reactogenic in allergic patients, hampering their use in therapeutic settings. In this work, we utilize a peptide-based self-assembling nanofiber platform to design allergen vaccines against allergen B-cell epitopes that do not elicit systemic anaphylaxis when administered subcutaneously to allergic mice. We show that, in contrast to protein vaccines, nanofiber vaccines prevent leakage of allergen material into the vascular compartment, a feature that likely underpins their reduced systemic reactogenicity. Further, we show that our allergen vaccine platform elicits therapeutic IgG antibody responses capable of desensitizing allergic mice to allergen-induced Type I hypersensitivity reactions. Finally, we have demonstrated a proof-of-concept for the therapeutic potential of nanofiber-based peanut allergen vaccines directed against peanut allergen-derived epitopes. ... [Read More]

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Data Citation
  • Cossette, B. J., Shetty, S., Issah, L. A., & Collier, J. H. (2024). Data from: Self-assembling allergen vaccine platform raises therapeutic allergen-specific IgG responses without induction of systemic allergic responses. Duke Research Data Repository. https://doi.org/10.7924/r4v40xs2n
DOI
  • 10.7924/r4v40xs2n
Publication Date
ARK
  • ark:/87924/r4v40xs2n
Collection Dates
  • July 12, 2021 to April 20, 2023
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  • Cossette, B. J., Shetty, S., Issah, L. A., & Collier, J. H. (2024). Self-assembling allergen vaccine platform raises therapeutic allergen-specific IgG responses without induction of systemic allergic responses. ACS Biomaterials Science & Engineering,  https://doi.org/10.1021/acsbiomaterials.3c01945
Funding Agency
  • National Institutes of Health
Grant Number
  • 1R21AI164740
Title
  • Data from: Self-assembling allergen vaccine platform raises therapeutic allergen-specific IgG responses without induction of systemic allergic responses
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