Data from: RNA sequencing of rabbit placentas exposed to a PFAS-mixture

• A mixture of per and polyfluoroalkyl substances (PFAS) are found in drinking water, diet, and household dust. These environmental contaminants are detected in up to 99% of human serum samples; yet very little is known about how exposures to exposure to mixtures of these compounds affect maternal and fetal health during pregnancy. We investigated the maternal, fetal, and placental outcomes after maternal exposure to an environmentally relevant PFAS-mixture during pregnancy in a New Zealand White (NZW) rabbit model. Female NZW rabbits were supplied control (no detectable PFAS levels) or PFAS-contaminated drinking water, which was formulated with PFAS to resemble levels measured in tap water collected from Pittsboro, NC (10 PFAS compounds; total PFAS load = 758.6 ng/L). Maternal, fetal, and placental outcomes were evaluated at necropsy. Further, dysregulated gene expression in the placenta was determined by RNA sequencing. 14 genes (p<0.1) were identified as significantly different, 9 of which are associated with adverse placental function related to pregnancy complications. ... [Read More]

Total Size

13 files (26.2 GB)

Data Citation

• Feng, L. & Crute, C. E. (2021). Data from: RNA sequencing of rabbit placentas exposed to a PFAS-mixture. Duke Research Data Repository. https://doi.org/10.7924/r4w66k88z

Creator

• Feng, Liping
• Crute, Christine E.

DOI

• 10.7924/r4w66k88z

Subject

• Placenta
• Perfluorinated chemicals
• Rabbits

Publication Date

• December 7, 2021

ARK

• ark:/87924/r4w66k88z

Publisher

• Duke Research Data Repository

Collection Dates

• 21-Sep

Type

• Dataset

Format

• fastq.gz

Related Materials

• Crute, C. E., Hall, S. M., Landon, C. D., Garner, A., Everitt, J. I., Zhang, S., Blake, B., Olofsson, D., Chen, H., Murphy, S. K., Stapleton, H. M., & Feng, L. (2022). Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a new zealand white (NZW) rabbit model. The Science of the Total Environment, 838(Pt 4), 156499-156499.  https://doi.org/10.1016/j.scitotenv.2022.156499

Contact

• liping.feng@duke.edu

License

• Creative Commons CC0 1.0 Universal

Title

• Data from: RNA sequencing of rabbit placentas exposed to a PFAS-mixture

License

• http://creativecommons.org/publicdomain/zero/1.0/

Repository

• Duke Research Data Repository

Thumbnail	Title	Date Uploaded		Actions
	PFASmix-2_S37_L002_R2_001.fastq.gz	2021-12-07	Public	Get file from Globus
	PFASmix-3_S38_L002_R1_001.fastq.gz	2021-12-07	Public	Get file from Globus
	PFASmix-3_S38_L002_R2_001.fastq.gz	2021-12-07	Public	Get file from Globus