Data from: Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance

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  • Reversible block of nerve conduction using kilohertz frequency electrical signals has substantial potential for treatment of disease. However, the ability to block nerve fibers selectively is limited by poor understanding of the relationship between waveform parameters and the nerve fibers that are blocked. Previous in vivo studies reported non-monotonic relationships between block signal frequency and block threshold, suggesting the potential for fiber-selective block. However, the mechanisms of non-monotonic block thresholds were unclear, and these findings were not replicated in a subsequent in vivo study. We used high-fidelity computational models and in vivo experiments in anesthetized rats to show that non-monotonic threshold-frequency relationships do occur, that they result from amplitude- and frequency-dependent charge imbalances that cause a shift between kilohertz frequency and direct current block regimes, and that these relationships can differ across fiber diameters such that smaller fibers can be blocked at lower thresholds than larger fibers. These results reconcile previous contradictory studies, clarify the mechanisms of interaction between kilohertz frequency and direct current block, and demonstrate the potential for selective block of small fiber diameters. ... [Read More]

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6 files (73.1 KB)
Data Citation
  • Peña, E., Pelot, N. A., & Grill, W. M. (2021). Data from: Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance. Duke Research Data Repository. https://doi.org/10.7924/r4pn94v5h
DOI
  • 10.7924/r4pn94v5h
Publication Date
ARK
  • ark:/87924/r4pn94v5h
Collection Dates
  • Apr 2019 - Mar 2020
Type
Format
Related Materials
  • Peña, E., Pelot, N.A. & Grill, W.M. Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance. Sci Rep 11, 5077 (2021).  https://doi.org/10.1038/s41598-021-84503-3
Funding Agency
  • NIH SPARC Initiative, Pratt School of Engineering Faculty Discretionary Fund
Grant Number
  • OT2 OD025340
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Title
  • Data from: Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance
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Thumbnail Title Date Uploaded Visibility Actions
file details README.txt 2021-01-25 Public Download
file details in_silico_DC_vs_KHF_components.csv 2021-01-25 Public Download
file details in_silico_amp_and_freq_dep_thresholds.csv 2021-01-25 Public Download
file details in_silico_const_and_amp_dep_DC_thresh.csv 2021-01-25 Public Download
file details in_silico_thresholds_across_fiberD.csv 2021-01-25 Public Download
file details in_vivo_amp_and_freq_dep_thresholds.csv 2021-01-25 Public Download

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