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- Objective. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for the motor symptoms of Parkinson's disease, although its mechanism of action is uncertain. Previous work has demonstrated that a critical component to its mechanism may be the activation of the primary motor cortex (M1) via the antidromic firing of neurons within the hyperdirect pathway from STN to M1. This antidromic firing exhibits high rates of spike failure when stimulated at high frequencies, and the spike failure rate appears to correlate with DBS efficacy. This synchronous antidromic spiking takes the form of a short-latency evoked potential in electrocorticography (ECoG) recordings of M1, with the magnitude of the cortical evoked potential (cEP) similarly declining at high stimulation frequencies. In this study, we aimed to characterize the cEP in response to various stimulation conditions and to determine whether changes in the cEP correlate with symptom reduction from DBS. Approach. We used the unilateral 6-hydroxydopamine lesioned rat model in female, Sprague Dawley rats, with stimulating electrodes implanted in the STN and the ECoG recorded above M1. We then recorded the cEP during various stimulation conditions and while performing behavioral assessments of hypokinetic symptoms. Main results. We found that the cEP is strongly affected by stimulation conditions, with the cEP magnitude declining and cEP latency increasing with higher stimulation frequencies. These effects occur over multiple minutes, and likely with multiple time-scales. Additionally, the cEP magnitude and latency each correlate strongly with symptom reduction from DBS, with superior correlations to conventional spectral-based biomarkers from ECoG. Significance. This study demonstrates the potential clinical utility of the cEP as a biomarker for symptom reduction from DBS, which may be used in determining proper lead location, stimulation parameter selection, or closed-loop control. Additionally, it provides further insight into the cortical mechanism by which DBS relieves symptoms, suggesting that it may be related to a potential desynchronizing effect caused by high rates of sporadic antidromic spike failure during high frequency DBS. ... [Read More]
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- Total Size
- 11 files (1.05 MB)
- Data Citation
- Cassar, I. R., & Grill, W. M. (2021). Data from: The cortical evoked potential as a biomarker for deep brain stimulation efficacy. Duke Research Data Repository. https://doi.org/10.7924/r4r78d86s
- Title
- Data from: The cortical evoked potential as a biomarker for deep brain stimulation efficacy
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DOI
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Publication Date
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2
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10.7924/r47s7t64c
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This dataset was updated with a new supplemental PDF file.
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2022-02-03
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10.7924/r4r78d86s
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2021-05-17
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