Data from: An atlas of genetic variation linking pathogen-induced cellular traits to human disease

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Pathogens have been a strong driving force for natural selection. Therefore, understanding how human genetic differences impact infection-related cellular traits can mechanistically link genetic variation to disease susceptibility. Here we report the Hi-HOST Phenome Project (H2P2): a catalog of cellular genome-wide association studies (GWAS) comprising 79 infection-related phenotypes in response to 8 pathogens in 528 lymphoblastoid cell lines. Seventeen loci surpass genome-wide significance for infection-associated phenotypes ranging from pathogen replication to cytokine production. We combined H2P2 with clinical association data from patients to identify a SNP near CXCL10 as a risk factor for inflammatory bowel disease. A SNP in the transcriptional repressor ZBTB20 demonstrated pleiotropy, likely through suppression of multiple target genes, and was associated with viral hepatitis. These data are available on a web portal to facilitate interpreting human genome variation through the lens of cell biology and should serve as a rich resource for the research community. ... [Read More]

Data Citation

Ko, D., & Wang, L. (2022). Data from: An atlas of genetic variation linking pathogen-induced cellular traits to human disease. Duke Research Data Repository. https://doi.org/10.7924/r4v125f95

Creator: Wang, Liuyang
Ko, Dennis
DOI: 10.7924/r4v125f95
Subject: Genome-wide association study
Lymphoblastoid cell line
Electronic medical record
Phewas
Heritability
Eldelumab
Pleiotropy
ZBTB20
Immune quantitative trait locus
CXCL10
Publication Date: May 6, 2022
ARK: ark:/87924/r4v125f95
Affiliation: Molecular Genetics and Microbiology
Publisher: Duke Research Data Repository
Type: Dataset
Format: GZ
TXT
Related Materials: HI-Host Phenome Project: http://h2p2.oit.duke.edu/H2P2Home/
Wang, L. et al. (2018).An atlas of genetic variation linking pathogen-induced cellular traits to human disease. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2018.07.007
Contact: Dennis Ko, https://orcid.org/0000-0002-0113-5981, dennis.ko@duke.edu, 919-684-5834
License: Creative Commons CC0 1.0 Universal
Title: Data from: An atlas of genetic variation linking pathogen-induced cellular traits to human disease
License: http://creativecommons.org/publicdomain/zero/1.0/
Repository: Duke Research Data Repository

Title	Date Uploaded	Visibility	Actions
WangKo_Readme.txt	2022-05-06	Public	Download
Cells_ml_after_3_days_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download
Cells_ml_after_3_days_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download
Chlamydia_27hr_cell_death_BG_subtracted_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download
Chlamydia_27hr_GFP_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download
Chlamydia_27hr_medianGFP_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download
Chlamydia_46hr_GFP_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download
Chlamydia_46hr_highGFP_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download
Chlamydia_70hr_cell_death_BG_sub_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download
Chlamydia_70hr_GFP_Meannew7.qfam.parents.perm_rsID.txt.gz	2022-05-06	Public	Download

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