- A model for antibiotic accumulation in bacterial biofilm microcolonies utilizing heterogenous porosity and attachment site profiles replicated the periphery sequestration reported in prior experimental studies on Pseudomonas aeruginosa PAO1 biofilm cell clusters. These P. aeruginosa cell clusters are in vitro models of the chronic P. aeruginosa infections in cystic fibrosis patients which display recalcitrance to antibiotic treatments, leading to exacerbated morbidity and mortality. This resistance has been partially attributed to periphery sequestration, where antibiotics fail to penetrate biofilm cell clusters. The physical phenomena driving this periphery sequestration have not been definitively established. This paper introduces mathematical models to account for two proposed physical phenomena driving periphery ... [Read More]
- Total Size
- 123 files (199 MB)
- Data Citation
- Prince, J., & Jones, A. D., III. (2023). Data and scripts from: Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics in Pseudomonas aeruginosa PAO1 microcolonies. Duke Research Data Repository. https://doi.org/10.7924/r4pr80j7f
- DOI
- 10.7924/r4pr80j7f
- Publication Date
- November 2, 2023
- ARK
- ark:/87924/r4pr80j7f
- Affiliation
- Publisher
- Type
- Related Materials
- Funding Agency
- National Institute of General Medical Sciences
- National Institutes of Health
- Grant Number
- NIH R35 GM142898
- Contact
- A-Andrew D. Jones III: https://orcid.org/0000-0003-3840-8039. andrew.jones3@duke.edu
- Title
- Data and scripts from: Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics in Pseudomonas aeruginosa PAO1 microcolonies
- Repository
