Data from: Spatiotemporal Parameters for Energy Efficient Kilohertz-Frequency Nerve Block with Low Onset Response

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  • Background: Electrical nerve conduction block has great potential for treatment of disease through reversible and local inactivation of somatic and autonomic nerves. However, the relatively high energy requirements and the presence of undesired excitation at the onset of the kilohertz-frequency (KHF) signals used for block pose obstacles to effective translation. Frequency, electrode geometry, and waveform shape are known to influence block threshold and onset response, but available data provide a limited understanding of how to select these parameters to optimize nerve block. Methods: We evaluated KHF nerve block in rat tibial nerve across frequencies (5-60 kHz), electrode geometries (monopolar, bipolar, and tripolar), and waveform shapes. We present a novel Fourier-based method for constructing composite signals that systematically sample the KHF waveform design space. Results: The lowest frequencies capable of blocking (5-16 kHz) were not the most energy-efficient among the tested frequencies. Further, bipolar cuffs required the largest current and power to block, monopolar cuffs required the lowest current, and both tripolar and monopolar cuffs required the lowest power. Tripolar cuffs produced the smallest onset response across frequencies. Composite signals comprised of a first harmonic sinusoid at fundamental frequency (f0) superposed on a second harmonic sinusoid at 2f0 could block at lower threshold and lower onset response compared to the constituent sinusoids alone. This effect was strongly dependent on the phase of the second harmonic and on the relative amplitudes of the first and second harmonics. This effect was also dependent on electrode geometry: monopolar and tripolar cuffs showed clear composite signal effects in most experiments; bipolar cuffs showed no clear effects in most experiments. Conclusions: Our data provide novel information about block threshold and onset response at the boundary of frequencies that can block. Our results also show an interaction between spatial (cuff geometry) and temporal (frequency and waveform shape) parameters. Finally, while previous studies suggested that temporal parameters could reduce onset response only in exchange for increased block threshold (or vice versa), our results show that waveform shape influences KHF response in ways that can be exploited to reduce both energy and onset responses. ... [Read More]

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6 files (332 KB)
Data Citation
  • Peña, E., Pelot, N. A., Grill, W. M. (2023). Data from: Spatiotemporal Parameters for Energy Efficient Kilohertz-Frequency Nerve Block with Low Onset Response. Duke Research Data Repository. https://doi.org/10.7924/r4w37z317
DOI
  • 10.7924/r4w37z317
Publication Date
ARK
  • ark:/87924/r4w37z317
Collection Dates
  • 9 Sept 2021 - 23 Feb 2022
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Related Materials
  • Peña, E., Pelot, N. A., & Grill, W. M. (2023). Spatiotemporal parameters for energy efficient kilohertz-frequency nerve block with low onset response. Journal of Neuroengineering and Rehabilitation, 20(1), 72-72.  https://doi.org/10.1186/s12984-023-01195-8
Funding Agency
  • Duke University Office of Translation and Commercialization
  • Pratt School of Engineering Faculty Discretionary Fund
  • National Institutes of Health
Grant Number
  • NIH SPARC Initiative (OT2 OD025340)
  • NIH R01 NS126376
Title
  • Data from: Spatiotemporal Parameters for Energy Efficient Kilohertz-Frequency Nerve Block with Low Onset Response
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Thumbnail Title Date Uploaded Visibility Actions
file details composite_signal_tests_data_table.mat 2023-05-30 Public Download
file details frequency_tests_data_table_AUC.mat 2023-05-30 Public Download
file details frequency_tests_data_table_max.mat 2023-05-30 Public Download
file details minimum_blocking_frequency_posthoc_analysis_v3.xlsx 2023-05-30 Public Download
file details code_to_analyze_and_plot_data.zip 2023-06-01 Public Download
file details README.txt 2023-06-01 Public Download

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