Data from: Delivery of angiogenic therapy from flowable hyaluronic acid porous scaffolds results in functional improvement without anti-inflammatory agents

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We have previously developed a hyaluronic acid (HA)-based hydrogel that delivered heparin nanoparticles alone, to reduce glial reactivity, and heparin nanoparticles with vascular endothelial growth factor (VEGF) bound to their surface, to promote angiogenesis. However, the inclusion of the naked heparin nanoparticles warranted concern over the development of bleeding complications. In this dataset, we explore how HA-based microporous annealed particle (MAP) scaffolds functionalized with VEGF coated heparin nanoparticles can both reduce glial reactivity and promote angiogenesis - without the inclusion of free heparin nanoparticles. We show that our updated design successfully promotes de novo tissue formation, including the development of mature vessels and neurite sprouting, and leads to functional improvement in a photothrombotic stroke model. In addition, we find increased astrocyte infiltration into the infarct site correlated with mature vessel formation. This work demonstrates how our biomaterial design can enhance endogenous regeneration post-stroke while eliminating the need for excess heparin.

The dataset included here contains the data needed to recreate the figures in our published article. ... [Read More]

Data Citation

Erning, K., Wilson, K. L., Smith, C. S., Nguyen, L., Joseph, N. I., Irengo, R., Cao, L. Y., Cumaran, M., Shi, Y., Lyu, S., Riley, L., Dunn, T. W., Carmichael, S. T., & Segura, T. (2025). Data from: Delivery of angiogenic therapy from flowable hyaluronic acid porous scaffolds results in functional improvement without anti-inflammatory agents. Duke Research Data Repository. https://doi.org/10.7924/r4q81k13n

Creator: Erning, Kevin
Carmichael, S. Thomas
Irengo, Rachel
Cao, Lauren Y
Cumaran, Mohanapriya
Riley, Lindsay
Dunn, Timothy W
Wilson, Katrina L
Shi, Yi
Lyu, Sihan
Smith, Cara S
Joseph, Neica I
Segura, Tatiana
Nguyen, Long
DOI: 10.7924/r4q81k13n
Subject: Vascular endothelial growth factors (VEGF)
Microporous Annealed Particle Scaffold
Granular Scaffold
Biomedical engineering
Stroke
Publication Date: March 18, 2025
ARK: ark:/87924/r4q81k13n
Contributor: Notini, Maria
Affiliation: Dermatology
Neurology
Biomedical Engineering
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles
Publisher: Duke Research Data Repository
Type: Dataset
Format: ND2
CSV
TIFF
PZFX
PRISM
XLSX
Funding Agency: National Institutes of Health
National Institute of Neurological Disorders and Stroke
National Institute on Drug Abuse
Grant Number: R34DA059512
R01NS079691
NS079691
Contact: Tatiana Segura, https://orcid.org/0000-0003-1569-8686, tatiana.segura@duke.edu
License: Creative Commons BY-NC Attribution-NonCommercial 4.0 International
Title: Data from: Delivery of angiogenic therapy from flowable hyaluronic acid porous scaffolds results in functional improvement without anti-inflammatory agents
License: https://creativecommons.org/licenses/by-nc/4.0/
Repository: Duke Research Data Repository

Title	Date Uploaded	Visibility	Actions
Figure 1.zip	2025-03-18	Public	Download
Figure 2.zip	2025-03-18	Public	Get file from Globus
Figure 3.zip	2025-03-18	Public	Get file from Globus
Figure 4.zip	2025-03-18	Public	Get file from Globus
Figure 5.zip	2025-03-18	Public	Get file from Globus
README.txt	2025-03-18	Public	Download
Supplemental Information.zip	2025-03-18	Public	Get file from Globus

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