- Diversity in the human genome is one factor that confers resistance and susceptibility to infectious diseases. This is observed most dramatically during pandemics, where individuals exhibit large differences in risk and clinical outcomes against a pathogen infecting large portions of the world’s populations. Here, we developed scHi-HOST (single cell High-throughput Human in vitrO Susceptibility Testing), a method for rapidly identifying genetic variants that confer resistance and susceptibility to pathogens. scHi-HOST leverages scRNA-seq (single-cell RNA-sequencing) to simultaneously assign genetic identity to individual cells in mixed infections of cell lines of European, African, and Asian origin, reveal associated genetic variants for viral entry and replication, and identify expression ... [Read More]
- Total Size
- 16 files (1.34 GB)
- Data Citation
- Ko, D., Wang, L., & Schott, B. (2022). Data from: Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus. Duke Research Data Repository. https://doi.org/10.7924/r4g163n0s
- DOI
- 10.7924/r4g163n0s
- Publication Date
- January 27, 2022
- ARK
- ark:/87924/r4g163n0s
- Publisher
- Type
- Contact
- Liuyang Wang, https://orcid.org/0000-0001-9556-2361
- Title
- Data from: Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus
- Repository
Thumbnail | Title | Date Uploaded | Actions | |
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SchottWangKo_DATASET_Readme.txt | 2022-01-27 | Download | |
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scHH_IAV_SexGeno2PCsGexLibSize_RASQUAL_eQTLs_qval0.05.csv.gz | 2022-01-27 | Download | |
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scHH_Uninfected_SexGeno2PCsGexLibSize_RASQUAL_eQTLs_qval0.05.csv.gz | 2022-01-27 | Download | |
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scHH_MeanViralReads_AllCells_EMMAX_gwasumstat.txt.gz | 2022-01-27 | Download | |
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IAV_SeuratMetadata.csv | 2022-02-02 | Download | |
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PR8ViralBurden_scHH_LGC.csv | 2022-02-02 | Download | |
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scHH_combined_PseudoBulkRNAseq_NormalizedCountMatrix.csv | 2022-02-02 | Download | |
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scHH_CombinedPhenotype.csv | 2022-02-02 | Download | |
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scHH_LGC_PseudoBulkRNAseq_NormalizedCountMatrix.csv | 2022-02-02 | Download | |
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Uninfected_SeuratMetadata.csv | 2022-02-02 | Download |