- The delivery of kilohertz frequency alternating current (KHFAC) generates rapid, controlled, and reversible conduction block in motor, sensory, and autonomic nerves, but causes transient activation of action potentials at the onset of the blocking current. We implemented a novel engineering optimization approach to design blocking waveforms that eliminated the onset response by moving voltage-gated Na+ channels (VGSCs) to closed-state inactivation (CSI) without first opening. We used computational models and particle swarm optimization (PSO) to design a charge-balanced 10 kHz biphasic current waveform that produced conduction block without onset firing in peripheral axons at specific locations and with specific diameters. The results indicate that it is possible ... [Read More]
- Total Size
- 78 files (66.7 MB)
- Data Citation
- Yi, G. & Grill, W. M. (2020). Data and code from: Waveforms optimized to produce closed-state Na+ inactivation eliminate onset response in nerve conduction block. Duke Research Data Repository. https://doi.org/10.7924/r4z31t79k
- Creator
- DOI
- 10.7924/r4z31t79k
- Publication Date
- May 19, 2020
- ARK
- ark:/87924/r4z31t79k
- Affiliation
- Publisher
- Type
- Related Materials
- Contact
- Warren M. Grill, 0000-0001-5240-6588, warren.grill@duke.edu
- Title
- Data and code from: Waveforms optimized to produce closed-state Na+ inactivation eliminate onset response in nerve conduction block
- Repository
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
README.txt | 2020-05-19 | Download | |
|
Generating Figures | 2020-05-19 | ||
|
Hybrid_MRG.zip | 2020-05-19 | Download | |
|
|
PSO_KHFAC.zip | 2020-05-19 | Download |