Images from: Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche

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  • Glioblastoma (GBM) remains an untreatable malignant tumor with poor patient outcomes, characterized by palisading necrosis and microvascular proliferation. While single-cell technology made it possible to characterize different lineage of glioma cells into neural progenitor-like (NPC-like), oligodendrocyte-progenitor-like (OPC-like), astrocyte-like (AC-like) and mesenchymal like (MES-like) states, it does not capture the spatial localization of these tumor cell states. Spatial transcriptomics empowers the study of the spatial organization of different cell types and tumor cell states and allows for the selection of regions of interest to investigate region-specific and cell-type-specific pathways. We obtained paired 10x Chromium single-nuclei RNA-sequencing (snRNA-seq) and 10x Visium spatial transcriptomics data from three GBM patients to interrogate the GBM microenvironment. Here, we have deposited the high resolution hematoxylin- and eosin-stained (H&E) images associated with the spatial transcriptomic data. The spatial transcriptomic data is restricted and must be housed elsewhere. ... [Read More]

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4 files (3.27 GB)
Data Citation
  • Liu, M., Ji, Z., Jain, V., Smith, V. L., Hocke, E., Patel, A. P., McLendon, R. E., Ashley, D. M., Gregory, S. G., & Lopez, G. Y. (2024). Images from: Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche. Duke Research Data Repository. https://doi.org/10.7924/r4nk3k26s
DOI
  • 10.7924/r4nk3k26s
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  • ark:/87924/r4nk3k26s
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Related Materials
  • Liu, M., Ji, Z., Jain, V., Smith, V. L., Hocke, E., Patel, A. P., McLendon, R. E., Ashley, D. M., Gregory, S. G., & López, G. Y. (2024). Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche. Acta neuropathologica communications, 12(1), 64.  https://doi.org/10.1186/s40478-024-01769-0
Funding Agency
  • National Center for Advancing Translational Sciences
  • National Cancer Institute
Grant Number
  • 1KL2TR002554
  • 5P50CA190991
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  • Images from: Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche
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file details 18-0282 Image.tif 2024-03-29 Public Download
file details 19-0142 Image.tif 2024-03-29 Public Download
file details 19-0341 Image.tif 2024-03-29 Public Download
file details README.txt 2024-03-29 Public Download

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