- Human genetic diversity can reveal critical factors in host-pathogen interactions. This is especially useful for human-restricted pathogens like Salmonella enterica serovar Typhi (S. Typhi), the cause of Typhoid fever. One key dynamic during infection is competition for nutrients: host cells attempt to restrict intracellular replication by depriving bacteria of key nutrients or delivering toxic metabolites in a process called nutritional immunity. Here, a cellular genome-wide association study of intracellular replication by S. Typhi in nearly a thousand cell lines from around the world and extensive follow-up using intracellular S. Typhi transcriptomics and manipulation of magnesium concentrations demonstrates that the divalent cation channel mucolipin-2 (MCOLN2) restricts S. ... [Read More]
- Total Size
- 2 files (672 MB)
- Data Citation
- Ko, D., Gibbs, K., & Wang, L. (2022). Data from: Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation. Duke Research Data Repository. https://doi.org/10.7924/r4x92bd76
- DOI
- 10.7924/r4x92bd76
- Publication Date
- May 4, 2022
- ARK
- ark:/87924/r4x92bd76
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- Title
- Data from: Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation
- Repository
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
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GibbsKo_DATASET_Readme.txt | 2022-05-04 | Download | |
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GibbsKo_HiHOST_SummaryStats_STyphiReplication.txt | 2022-05-04 | Download |