- The anaphylatoxins C3a and C5a are products of the complement cascade that play important and interrelated roles in health and disease. Both are potential targets for anti-inflammatory active immunotherapies in which a patient's own immune system is stimulated to produce therapeutic immune responses against problematic self-molecules. However, the complex and time-dependent interrelations between the two molecules make dual targeting challenging. To investigate a dual-target active immunotherapy against C3a and C5a and to systematically study the effect of varied degrees of responses against both targets, the study employed self-assembled peptide immunogens capable of displaying a broad range of epitope compositions and Design-of-Experiments (DoE) approaches. Peptide nanofibers contained ... [Read More]
- Total Size
- 2 files (6.79 MB)
- Data Citation
- Freire Haddad, H., Roe, E. F., Xie Fu, V., Curvino, E. J., & Collier, J. H. (2024). Data from: Multi-target immunotherapy diminishes complement anaphylatoxin activity in acute inflammation. Duke Research Data Repository. https://doi.org/10.7924/r4j108n44
- DOI
- 10.7924/r4j108n44
- Subject
- Publication Date
- November 21, 2024
- ARK
- ark:/87924/r4j108n44
- Affiliation
- Publisher
- Type
- Related Materials
- Funding Agency
- National Science Foundation
- National Institutes of Health
- Grant Number
- DGE-1644868
- 1 R01 AI172151
- Contact
- Joel Collier, joel.collier@duke.edu, https://orcid.org/0000-0003-3536-4827
- Title
- Data from: Multi-target immunotherapy diminishes complement anaphylatoxin activity in acute inflammation
- Repository
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
C3a C5a Paper Data.xlsx | 2024-11-21 | Download | |
|
README.txt | 2024-11-21 | Download |