- Animals vocalize only in certain behavioral contexts, but the circuits and synapses through which forebrain neurons trigger or suppress vocalization remain unknown. Here we used transsynaptic tracing to identify two populations of inhibitory neurons that lie upstream of neurons in the periaqueductal gray that gate the production of ultrasonic vocalizations in mice (i.e., PAG-USV neurons). Activating PAG-projecting neurons in the preoptic hypothalamus (POAPAG neurons) elicited USV production in the absence of social cues. In contrast, activating PAG-projecting neurons in the central-medial boundary zone of the amygdala (AmgC/M-PAG neurons) transiently suppressed USV production without disrupting non-vocal social behavior. Optogenetics-assisted circuit mapping in brain slices revealed that POAPAG ... [Read More]
- Total Size
- 315 files (53.3 GB)
- Data Citation
- Michael, V., Goffinet, J. Pearson, J., Wang, F., Tschida, K., & Mooney, R. (2020). Data and scripts from: Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization. Duke Research Data Repository. https://doi.org/10.7924/r4cz38d99.
- DOI
- 10.7924/r4cz38d99
- Subject
- Publication Date
- December 18, 2020
- ARK
- ark:/87924/r4cz38d99
- Publisher
- Collection Dates
- 2018-2020
- Language
- Type
- Related Materials
- Funding Agency
- NIH
- Grant Number
- DC 013826 & MH 117778
- Contact
- Valerie Michael: valerie.michael@duke.edu, ORCID: 0000-0003-3288-9409
- Title
- Data and scripts from: Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization
- Repository
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README.txt | 2020-12-18 | Download | |
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Audio and video | 2020-12-18 | ||
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Confonal images | 2020-12-18 | ||
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Matlab code | 2020-12-18 | ||
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Slice physiology | 2020-12-18 |