Data from: RNA sequencing of rabbit placentas exposed to PFBS

• Per- and polyfluoralkyl substances (PFAS) are persistent environmental contaminants, and
  human exposure is ubiquitous and associated with many adverse health outcomes. In recognition of these health risks, legacy PFAS compounds such as perfluorooctane sulfonate (PFOS) have been replaced with “safer” alternatives such as perfluorobutane sulfonate (PFBS), although their toxicity is largely unknown. Recent studies suggest that maternal PFAS exposure leads to adverse pregnancy outcomes including maternal hypertensive disorders, thyroid hormone disruption, and low birth weight, though the epidemiologic literature varies and biological mechanisms remain undetermined. Of concern, maternal PFBS exposure was recently associated with an increased risk of preeclampsia, a life-threatening pregnancy complication resulting from dysregulated placentation. Using our established rabbit model, dams were exposed to PFBS-contaminated drinking water throughout pregnancy. Pregnancy outcomes were evaluated, including placentation. Differential gene expression was evaluated in rabbit placentas by RNAseqencing. ... [Read More]

Total Size

19 files (28.6 GB)

Data Citation

• Feng, L. & Crute, C. E. (2021). Data from: RNA sequencing of rabbit placentas exposed to PFBS. Duke Research Data Repository. https://doi.org/10.7924/r43r0zt6t

Creator

• Feng, Liping
• Crute, Christine E

DOI

• 10.7924/r43r0zt6t

Subject

• Rabbits
• Perfluorinated chemicals
• Placenta

Publication Date

• December 7, 2021

ARK

• ark:/87924/r43r0zt6t

Affiliation

• Nicholas School of the Environment
• Obstetrics and Gynecology, School of Medicine

Publisher

• Duke Research Data Repository

Collection Dates

• September 2020 - September 2021

Type

• Dataset

Format

• fastq.gz

Related Materials

• Crute, C. E., Landon, C. D., Garner, A., Hall, S. M., Everitt, J. I., Zhang, S., Blake, B., Olofsson, D., Chen, H., Stapleton, H. M., Murphy, S. K., & Feng, L. (2023). Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: Evidence of adverse maternal and fetoplacental effects in new zealand white (NZW) rabbits. Toxicological Sciences, 191(2), 239-252.  https://doi.org/10.1093/toxsci/kfac126

Contact

• liping.feng@duke.edu

License

• Creative Commons CC0 1.0 Universal

Title

• Data from: RNA sequencing of rabbit placentas exposed to PFBS

License

• http://creativecommons.org/publicdomain/zero/1.0/

Repository

• Duke Research Data Repository