Data from: RNA sequencing of rabbit placentas exposed to PFBS


  • Per- and polyfluoralkyl substances (PFAS) are persistent environmental contaminants, and
    human exposure is ubiquitous and associated with many adverse health outcomes. In recognition of these health risks, legacy PFAS compounds such as perfluorooctane sulfonate (PFOS) have been replaced with “safer” alternatives such as perfluorobutane sulfonate (PFBS), although their toxicity is largely unknown. Recent studies suggest that maternal PFAS exposure leads to adverse pregnancy outcomes including maternal hypertensive disorders, thyroid hormone disruption, and low birth weight, though the epidemiologic literature varies and biological mechanisms remain undetermined. Of concern, maternal PFBS exposure was recently associated with an increased risk of preeclampsia, a life-threatening pregnancy complication resulting from dysregulated placentation. Using our established rabbit model, dams were exposed to PFBS-contaminated drinking water throughout pregnancy. Pregnancy outcomes were evaluated, including placentation. Differential gene expression was evaluated in rabbit placentas by RNAseqencing. ... [Read More]

Total Size
19 files (28.6 GB)
Data Citation
  • 10.7924/r43r0zt6t
Publication Date
  • ark:/87924/r43r0zt6t
Collection Dates
  • September 2020 - September 2021
  • Data from: RNA sequencing of rabbit placentas exposed to PFBS
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